讲座编号:jz-yjsb-2017-y071
讲座问题:Advances in targeting cyclic nucleotide phosphodiesterases
主 讲 人:柯衡明 教授 The University of North Carolina at Chapel Hill
讲座时间:2017年11月01日(周三)上午08:00
讲座所在:阜成路西校区教三332室
加入工具:食物学院全体师生,及全校对专题感兴趣的师生
主理单位:研究生院
承办单位:食物学院
主讲人简介:
柯衡明博士是美国北卡莱罗纳大学教堂山分校医学院的终身教授。在哈佛大学攻读博士时代,师从William N. Lipscomb 教授(1976年诺贝尔化学奖获得者),在结构生物学研究方面取得了天下着名的效果,已经解出了PDE等10类卵白质的晶体结构。在Cell,Science,Nature Struct. Biol.,Proc Natl Acad Sci U S A, J Biol Chem,J Med Chem.,Development,Biochem. Pharmacol.,Biochem J., J. Mol. Biol.等国际著名学术期刊上揭晓论文80余篇。是American Crystallographic Association,American Association for the Advancement of Science委员,J. Biological Sciences, Current Bioactive Compounds 编委,以及Proc. Natl. Acad. Sci., J. Mol. Biol.,J. Biol. Chem.,EMBO J.,Biochemistry,Structure,Protein: structure, function and genetics,Nature Structural Biology等顶级期刊的审稿人。
主讲内容:
Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides, their signalling pathways and, consequently, myriad biological responses in health and disease. Currently, a small number of PDE inhibitors are used clinically for treating the pathophysiological dysregulation of cyclic nucleotide signalling in several disorders, including erectile dysfunction, pulmonary hypertension, acute refractory cardiac failure, intermittent claudication and chronic obstructive pulmonary disease.